Humbja e flok\u00ebve dhe dihidrotestosteroni (DHT)
\nEdhe pse t\u00eb dy gjinit\u00eb mund t\u00eb prodhojn\u00eb androgjene, shumica e njer\u00ebzve i lidhin k\u00ebto hormone me meshkujt. Testosteroni sekretohet nga gj\u00ebndrat mbiveshkore tek t\u00eb dyja gjinit\u00eb, nga vezoret tek femrat dhe nga testikujt tek meshkujt. DHT \u00ebsht\u00eb nj\u00eb androgjen i fuqish\u00ebm i lidhur me r\u00ebnien e flok\u00ebve n\u00eb alopecin\u00eb androgjenetike dhe njihet si androgjeni m\u00eb i r\u00ebnd\u00ebsish\u00ebm n\u00eb papil\u00ebn dermale t\u00eb l\u00ebkur\u00ebs dhe folikulit t\u00eb flok\u00ebve. Ky hormon formohet kur testosteroni shnd\u00ebrrohet n\u00eb DHT nga enzima 5-alfa-reduktaz\u00eb. Ky transformim nuk ndodh n\u00eb testikuj apo vezore, por kryesisht n\u00eb indet periferike si l\u00ebkura.
\nP\u00ebr t\u00eb kuptuar pse burrat dhe grat\u00eb p\u00ebrjetojn\u00eb r\u00ebnie t\u00eb flok\u00ebve n\u00eb m\u00ebnyra t\u00eb ndryshme dhe p\u00ebr t\u00eb zhvilluar trajtime specifike p\u00ebr gjinin\u00eb, \u00ebsht\u00eb e nevojshme t\u00eb p\u00ebrcaktohet sinteza e DHT n\u00eb t\u00eb dy gjinit\u00eb. DHT \u00ebsht\u00eb hormoni m\u00eb i njohur q\u00eb rregullon r\u00ebnien e flok\u00ebve. Nj\u00eb kuptim m\u00eb i mir\u00eb i rolit t\u00eb DHT n\u00eb folikulat e flok\u00ebve do t\u00eb leht\u00ebsoj\u00eb zhvillimin e trajtimeve t\u00eb humbjes s\u00eb flok\u00ebve.
\nEdhe pse ka mbi 30 vjet prova q\u00eb DHT \u00ebsht\u00eb e lidhur me r\u00ebnien e flok\u00ebve n\u00eb l\u00ebkur\u00ebn e kok\u00ebs, kjo lidhje mbetet e vlefshme edhe sot. Prevalenca e alopecis\u00eb androgjenetike po rritet p\u00ebr shkak t\u00eb vonesave t\u00eb shtatz\u00ebnive t\u00eb para dhe faktor\u00ebve mjedisor\u00eb. P\u00ebr m\u00eb tep\u00ebr, gjithnj\u00eb e m\u00eb shum\u00eb gra po diagnostikohen me sindrom\u00ebn metabolike dhe sindrom\u00ebn e vezores policistike (PCOS), t\u00eb cilat t\u00eb dyja mund t\u00eb shkaktojn\u00eb prodhim t\u00eb tep\u00ebrt t\u00eb androgjenit dhe r\u00ebnie t\u00eb flok\u00ebve. Ky zhvillim nxiti p\u00ebrpjekjet p\u00ebr t\u00eb zhvilluar trajtime efektive, t\u00eb cilat fillimisht u fokusuan n\u00eb DHT dhe ende nxisin k\u00ebrkimin e alopecis\u00eb. Hulumtimet e fundit synojn\u00eb t\u00eb kuptojn\u00eb se si metabolizmi i androgjenit dhe rregullimi hormonal \u00e7ojn\u00eb n\u00eb rrallimin e flok\u00ebve t\u00eb lidhur me mosh\u00ebn.
\nRoli i DHT n\u00eb tkurrjen e folikulave t\u00eb flok\u00ebve
\nDHT \u00ebsht\u00eb e nevojshme p\u00ebr tkurrjen dhe p\u00ebrfundimin e folikulave t\u00eb flok\u00ebve pas pubertetit. Tkurrja e gj\u00ebndr\u00ebs s\u00eb flok\u00ebve, q\u00eb rezulton n\u00eb fije floku m\u00eb t\u00eb shkurtra dhe m\u00eb t\u00eb holla, quhet miniaturizim. Folikuli mund t\u00eb ndaloj\u00eb p\u00ebrfundimisht prodhimin e qimeve plot\u00ebsisht. DHT prek kryesisht folikulat e flok\u00ebve q\u00eb jan\u00eb t\u00eb ndjeshme ndaj androgjen\u00ebve. Tek njer\u00ebzit q\u00eb jan\u00eb gjenetikisht t\u00eb ndjesh\u00ebm ndaj DHT, prodhimi i DHT rritet gjat\u00eb adoleshenc\u00ebs, duke b\u00ebr\u00eb q\u00eb faza e anagjenit (rritjes) e folikulave t\u00eb flok\u00ebve t\u00eb shkurtohet dhe t\u00eb b\u00ebhet n\u00eb miniatur\u00eb. \u00c7do individ e p\u00ebrjeton k\u00ebt\u00eb proces ndryshe dhe me nj\u00eb rit\u00ebm m\u00eb t\u00eb ngadalt\u00eb.
\nReceptori androgjen \u00ebsht\u00eb nj\u00eb protein\u00eb q\u00eb ngjitet n\u00eb folikulat e ndjeshme t\u00eb flok\u00ebve dhe rregullon p\u00ebrgjigjen folikulare ndaj DHT. Studimet in vitro tregojn\u00eb se faktor\u00ebt q\u00eb ndikojn\u00eb n\u00eb funksionin e receptorit androgjen mund t\u00eb ndikojn\u00eb n\u00eb efektin e DHT n\u00eb folikulat e flok\u00ebve. Hulumtimet kan\u00eb zbuluar se rritja e p\u00ebrgjithshme e qimeve pubike, mjekr\u00ebs dhe sqetull\u00ebs mund t\u00eb parandalohet duke bllokuar receptorin androgjen. Me kalimin e koh\u00ebs, humbja e flok\u00ebve gjat\u00eb adoleshenc\u00ebs \u00ebsht\u00eb gjetur t\u00eb jet\u00eb e lidhur me rritjen e niveleve t\u00eb DHT n\u00eb epiderm\u00eb. Me kalimin e koh\u00ebs, humbja e flok\u00ebve gjat\u00eb adoleshenc\u00ebs \u00ebsht\u00eb gjetur t\u00eb jet\u00eb e lidhur me rritjen e niveleve t\u00eb DHT n\u00eb epiderm\u00eb. Studimet tregojn\u00eb nj\u00eb lidhje t\u00eb r\u00ebnd\u00ebsishme midis p\u00ebrqendrimit t\u00eb DHT dhe madh\u00ebsis\u00eb s\u00eb folikulave t\u00eb flok\u00ebve n\u00eb rajonet frontale dhe parietale t\u00eb kok\u00ebs. Nivelet e DHT rriten me madh\u00ebsin\u00eb e folikulave t\u00eb flok\u00ebve. Trajtime t\u00eb ndryshme q\u00eb ulin nivelet e DHT mund t\u00eb reduktojn\u00eb humbjen e flok\u00ebve duke ndaluar tkurrjen e gj\u00ebndrave t\u00eb flok\u00ebve. Humbja e flok\u00ebve n\u00eb pjes\u00ebn e pasme dhe n\u00eb an\u00ebt e kok\u00ebs \u00ebsht\u00eb e rrall\u00eb sepse k\u00ebtyre folikulave t\u00eb flok\u00ebve u mungojn\u00eb receptor\u00ebt DHT, duke i b\u00ebr\u00eb ato rezistente ndaj tkurrjes.
\nPredispozita trash\u00ebgimore dhe ndjeshm\u00ebria ndaj DHT
\nVe\u00e7an\u00ebrisht n\u00eb l\u00ebkur\u00ebn e kok\u00ebs, disa njer\u00ebz kan\u00eb folikula t\u00eb flok\u00ebve gjenetikisht “t\u00eb ndjeshme”. R\u00ebnia e flok\u00ebve mund t\u00eb ndodh\u00eb n\u00eb familje, si\u00e7 shihet n\u00eb alopecin\u00eb androgjenetike (tullac e zakonshme). Ndryshimet n\u00eb gjenin e receptorit androgjen mund t\u00eb ndikojn\u00eb n\u00eb rrezikun dhe ashp\u00ebrsin\u00eb e r\u00ebnies s\u00eb flok\u00ebve n\u00eb shkall\u00eb t\u00eb ndryshme. Meqen\u00ebse burrat kan\u00eb nivele m\u00eb t\u00eb larta t\u00eb DHT dhe testosteronit, alopecia androgjenetike \u00ebsht\u00eb m\u00eb e zakonshme se grat\u00eb. Thuhet se deri n\u00eb mosh\u00ebn 40 vje\u00e7, af\u00ebrsisht 70% e meshkujve kan\u00eb flok\u00eb t\u00eb holluar.
\nModelet e rrallimit t\u00eb flok\u00ebve jan\u00eb karakteristik\u00eb e nj\u00eb predispozicioni gjenetik ndaj DHT. Nj\u00eb lloj i ve\u00e7ant\u00eb i r\u00ebnies s\u00eb flok\u00ebve t\u00eb shkaktuar nga faktor\u00eb gjenetik\u00eb njihet si alopecia androgjenetike. 5-alfa-reduktaza \u00ebsht\u00eb nj\u00eb enzim\u00eb q\u00eb konverton testosteronin n\u00eb DHT, i cili ngjitet n\u00eb receptor\u00ebt e folikulave t\u00eb flok\u00ebve dhe shkakton r\u00ebnie t\u00eb flok\u00ebve. Folikujt q\u00eb vijn\u00eb n\u00eb kontakt me DHT p\u00ebrjetojn\u00eb nj\u00eb proces t\u00eb quajtur “miniaturizim” n\u00eb t\u00eb cilin fijet e flok\u00ebve gradualisht b\u00ebhen m\u00eb t\u00eb holla dhe m\u00eb t\u00eb shkurtra.
\nBllokuesit e DHT dhe trajtimet e r\u00ebnies s\u00eb flok\u00ebve
\nTrajtime t\u00eb shumta farmaceutike jan\u00eb krijuar n\u00eb nj\u00eb p\u00ebrpjekje p\u00ebr t\u00eb trajtuar r\u00ebnien e flok\u00ebve t\u00eb shkaktuar nga DHT. Dy barna q\u00eb frenojn\u00eb 5-alfa-reduktaz\u00ebn jan\u00eb finasteride dhe dutasteride; dutasteridi frenon izoenzim\u00ebn e tipit I. Nivelet e DHT bien n\u00eb p\u00ebrputhje me rrethanat. Bllokuesit e DHT p\u00ebrfshijn\u00eb nj\u00eb s\u00ebr\u00eb trajtimesh aktuale dhe suplemente ushqimore. Studimet klinike tregojn\u00eb se bllokuesit sistematik\u00eb t\u00eb DHT mund t\u00eb reduktojn\u00eb humbjen e flok\u00ebve me af\u00ebrsisht 50% brenda nj\u00eb viti. K\u00ebto medikamente mund t\u00eb ken\u00eb efekte t\u00eb pad\u00ebshiruara, duke e b\u00ebr\u00eb t\u00eb v\u00ebshtir\u00eb marrjen e tyre si\u00e7 p\u00ebrshkruhet n\u00eb afat t\u00eb gjat\u00eb.
\nVet\u00ebm disa njer\u00ebz reagojn\u00eb mir\u00eb ndaj bllokuesve t\u00eb DHT. Kjo mund t\u00eb jet\u00eb p\u00ebr shkak t\u00eb ndryshimeve n\u00eb m\u00ebnyr\u00ebn se si \u00e7do trup prodhon DHT ose kompleksitetit t\u00eb efekteve t\u00eb DHT n\u00eb ciklin e rritjes s\u00eb flok\u00ebve.
\nPrandaj, trajtimet e kombinuara q\u00eb kombinojn\u00eb frenuesit DHT me medikamente t\u00eb tjera p\u00ebr t\u00eb nxitur rritjen e flok\u00ebve jan\u00eb b\u00ebr\u00eb t\u00eb njohura. Megjithat\u00eb, efektiviteti i k\u00ebtyre trajtimeve \u00ebsht\u00eb ende i debatuar. Megjith\u00ebse gjetjet e p\u00ebrshkruara dhe nj\u00eb num\u00ebr i vog\u00ebl i rasteve studimore tregojn\u00eb sukses, k\u00ebrkime t\u00eb m\u00ebtejshme jan\u00eb t\u00eb nevojshme.
\nE ardhmja e trajtimeve t\u00eb r\u00ebnies s\u00eb flok\u00ebve
\nthekson rolin e r\u00ebnd\u00ebsish\u00ebm t\u00eb DH T n\u00eb r\u00ebnien e flok\u00ebve t\u00eb modelit mashkullor (alopecia androgjenetike) dhe s\u00ebmundje t\u00eb tjera q\u00eb lidhen me r\u00ebnien e flok\u00ebve.
\nFal\u00eb avancimit t\u00eb njohurive tona rreth biologjis\u00eb s\u00eb folikulave t\u00eb flok\u00ebve, jan\u00eb zhvilluar trajtime t\u00eb reja q\u00eb nxisin rritjen e flok\u00ebve. Studimet e ardhshme q\u00eb shqyrtojn\u00eb marr\u00ebdh\u00ebnien midis DHT dhe r\u00ebnies s\u00eb flok\u00ebve do t\u00eb fokusohen n\u00eb variantet gjenetike q\u00eb ndikojn\u00eb n\u00eb ndjeshm\u00ebrin\u00eb e folikulave t\u00eb flok\u00ebve ndaj DHT. P\u00ebrmir\u00ebsimi i trajtimeve t\u00eb r\u00ebnies s\u00eb flok\u00ebve do t\u00eb k\u00ebrkoj\u00eb eksplorimin e gjenetik\u00ebs s\u00eb ndjeshm\u00ebris\u00eb s\u00eb DHT dhe krijimin e trajtimeve q\u00eb synojn\u00eb enzim\u00ebn 5-alfa-reduktaz\u00eb.
\nMeqen\u00ebse frenuesit aktual\u00eb t\u00eb DHT dhe finasteride jan\u00eb tashm\u00eb t\u00eb aksesuesh\u00ebm, m\u00eb shum\u00eb opsione me invazivitet dhe efektivitet t\u00eb ndrysh\u00ebm ka t\u00eb ngjar\u00eb t\u00eb p\u00ebrfshihen n\u00eb nd\u00ebrhyrjet mjek\u00ebsore n\u00eb t\u00eb ardhmen. Zgjidhjet p\u00ebr kujdesin e flok\u00ebve t\u00eb p\u00ebrshtatura me profilin gjenetik t\u00eb \u00e7do individi po b\u00ebhen gjithashtu realitet. Tradicionalisht, transplantimi i flok\u00ebve dhe trajtimet me plazm\u00eb t\u00eb pasur me trombocite mund t\u00eb kombinohen me produkte speciale p\u00ebr kujdesin e flok\u00ebve p\u00ebr t\u00eb arritur rezultate m\u00eb t\u00eb mira.<\/p>\n","protected":false},"excerpt":{"rendered":"
Humbja e flok\u00ebve dhe dihidrotestosteroni (DHT) Edhe pse t\u00eb dy gjinit\u00eb mund t\u00eb prodhojn\u00eb androgjene, shumica e njer\u00ebzve i lidhin k\u00ebto hormone me meshkujt. Testosteroni sekretohet nga gj\u00ebndrat mbiveshkore tek t\u00eb dyja gjinit\u00eb, nga vezoret tek femrat dhe nga testikujt tek meshkujt. DHT \u00ebsht\u00eb nj\u00eb androgjen i fuqish\u00ebm i lidhur me r\u00ebnien e flok\u00ebve n\u00eb […]<\/p>\n","protected":false},"author":7,"featured_media":8456,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[],"class_list":["post-8455","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/posts\/8455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/comments?post=8455"}],"version-history":[{"count":1,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/posts\/8455\/revisions"}],"predecessor-version":[{"id":19648,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/posts\/8455\/revisions\/19648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/media\/8456"}],"wp:attachment":[{"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/media?parent=8455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/categories?post=8455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.smilehairclinic.com\/sq\/wp-json\/wp\/v2\/tags?post=8455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}